wgsea-package: Gene set enrichment analysis using Wilcoxon rank tests

In wgsea: Wilcoxon based gene set enrichment analysis

Description

Gene set enrichment analysis (GSEA) is typically based on tests derived from the Kolmogorov-Smirnov, which is underpowered and a need for simpler methods has been identified. The wgsea package contains functions for conducting GSEA using a Wilcoxon test to test for differences in the distribution of p values between SNPs within the gene set under test and a control set of SNPs.

Details

Package:	wgsea
Type:	Package
Version:	1.0
Date:	2012-04-18
License:	GPL

See the vignette for further details.

Author(s)

Chris Wallace <[e-mail]>

References

Irizarry, R. A.; Wang, C.; Zhou, Y. & Speed, T. P. Gene set enrichment analysis made simple. Stat Methods Med Res 2009, 18, 565-575

Heinig, M.; Petretto, E.; Wallace, C.; et al. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature 2010, 467, 460-464

Examples

vignette(package="wgsea")

Example output

Loading required package: snpStats
Loading required package: survival
Loading required package: Matrix
Vignettes in package 'wgsea':

wgsea                   wgsea (source, pdf)

wgsea documentation built on May 29, 2017, 7:02 p.m.