xlink: xlink: A package for genetic association models for...

In xlink: Genetic Association Models for X-Chromosome SNPS on Continuous, Binary and Survival Outcomes

Description

The expression of X-chromosome undergoes three possible biological processes: X-chromosome inactivation (XCI), escape of the X-chromosome inactivation (XCI-E),and skewed X-chromosome inactivation (XCI-S). To analyze the X-linked genetic association for phenotype such as continuous, binary, and time-to-event outcomes with the actual process unknown, we propose a unified approach of maximizing the likelihood or partial likelihood over all of the potential biological processes.

xlink functions

xlink_fit, select_output.

References

Xu, Wei, and Meiling Hao. 'A unified partial likelihood approach for X-chromosome association on time-to-event outcomes.' Genetic epidemiology 42.1 (2018): 80-94.

xlink documentation built on Aug. 21, 2019, 1:05 a.m.