IncrementsHSRBeta-class: 'IncrementsHSRBeta'

In 0liver0815/onc-crmpack-test: Object-Oriented Implementation of CRM Designs

Description

IncrementsHSRBeta is a class for limiting further increments using a Hard Safety Rule based on the Bin-Beta model. Increment control is based on the number of observed DLTs and number of subjects at each dose level. The probability of toxicity is calculated using a Bin-Beta model with prior (a,b). If the probability exceeds the threshold for a given dose, that dose and all doses above are excluded from further escalation. This is a hard safety rule that limits further escalation based on the observed data per dose level, independent from the underlying model.

IncrementsHSRBeta is a class for increments based on the Bin-Beta model. Increment control is based on the number of observed DLTs and number of subjects at each dose level. The probability of toxicity is calculated using a Bin-Beta model with prior (a,b). If the probability exceeds the threshold for a given dose, that dose and all doses above are excluded from further escalation. This is a hard safety rule that limits further escalation based on the observed data per dose level.

Usage

IncrementsHSRBeta(target = 0.3, prob = 0.95, a = 1, b = 1)

IncrementsHSRBeta(target = 0.3, prob = 0.95, a = 1, b = 1)

Arguments

target	(number) the target toxicity
prob	(number) the threshold probability for a dose being toxic
a	(number) shape parameter a>0 of probability distribution Beta (a,b)
b	(number) shape parameter b>0 of probability distribution Beta (a,b)

Slots

target

(proportion)
the target toxicity.

prob

(proportion)
the threshold probability for a dose being toxic.

a

(number)
shape parameter a>0 of probability distribution Beta (a,b).

b

(number)
shape parameter b>0 of probability distribution Beta (a,b).

target

(number)
the target toxicity

prob

(number)
the threshold probability for a dose being toxic

a

(number)
shape parameter a>0 of probability distribution Beta (a,b)

b

(number)
shape parameter b>0 of probability distribution Beta (a,b)

Examples

# Limit the escalation with a hard safety criteria to the doses that are below
# the first dose that is toxic with a probability of 0.95.
my_increments <- IncrementsHSRBeta(target = 0.3, prob = 0.95)

# Limit the escalation with a hard safety criteria to the doses that are below
# the first dose that is toxic with a probability of 0.95
my_increments <- IncrementsHSRBeta(target = 0.3, prob = 0.95)

0liver0815/onc-crmpack-test documentation built on Feb. 19, 2022, 12:25 a.m.