Description Details Slots Examples
This class can be used to combine multiple cohort size rules with the MIN operation.
cohortSizeList
contains all cohort size rules, which are again
objects of class CohortSize
. The minimum of these
individual cohort sizes is taken to give the final cohort size.
cohortSizeList
list of cohort size rules
1 2 3 4 5 6 7 8 9 10 11 12 13 14 | # Rule for having cohort of size 1 for doses <30
# and having cohort of size 3 for doses >=30
mySize1 <- CohortSizeRange(intervals = c(0, 10),
cohortSize = c(1, 3))
# Rule for having cohort of size 1 until no DLT were observed
# and having cohort of size 3 as soon as 1 DLT is observed
mySize2 <- CohortSizeDLT(DLTintervals=c(0, 1),
cohortSize=c(1, 3))
# Create a list of cohort size rules of class 'CohortSizeMax' which will then be
# combined with the 'min' operation
mySize <- CohortSizeMin(cohortSizeList=list(mySize1,
mySize2))
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