IncrementsSafetyStop-class: Increments control based on the number of observed DLTs This...
In 0liver0815/onc-crmpack-test: Object-Oriented Implementation of CRM Designs
Description
Increments control based on the number of observed DLTs
This is a safety rule that limits further escalation based on the
number of observed DLTs. The probability that a dose is toxic is calculated
using a Bin-Beta distribution with prior (a,b). If the probability exceeds
the threshold for a given dose, that dose and all doses above are excluded
from further escalation.
Slots
targetthe target toxicity
probthe threshold probability
prior.athe the first parameter of the prior Beta distribution
prior.bthe the second parameter of the prior Beta distribution
0liver0815/onc-crmpack-test documentation built on Feb. 19, 2022, 12:25 a.m.
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Description
Increments control based on the number of observed DLTs This is a safety rule that limits further escalation based on the number of observed DLTs. The probability that a dose is toxic is calculated using a Bin-Beta distribution with prior (a,b). If the probability exceeds the threshold for a given dose, that dose and all doses above are excluded from further escalation.
Slots
targetthe target toxicity
probthe threshold probability
prior.athe the first parameter of the prior Beta distribution
prior.bthe the second parameter of the prior Beta distribution
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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