NextBestMTDprob-class: The class with the input for finding the next best MTD...
In 0liver0815/onc-crmpack-test: Object-Oriented Implementation of CRM Designs
Description
The class with the input for finding the next best MTD estimate with highest
probability to be the MTD.
The dose which has the highest probability to be the MTD among the specified
doses is used as next best dose. The posterior is calculated for each
iteration and the maximum dose that is not toxic (below target) is determined.
The allocation criteria is calculated as the frequency of a dose being
selected as MTD. The dose with the highest allocation value is selected as
next best dose.
Slots
targetthe target toxicity probability
methodthe method used for calculating the allocation criteria
1=aggregate no dose safe with first dose
2=aggregate no dose safe with last dose
3=do not aggregate, but report the first dose as best next dose, in case 'no
dose is safe' has the highest allocation value. This follows the idea used for
the smallest distance to the target dose approach, where always a dose is
recommended, even though the lowest dose estimated is above target
0liver0815/onc-crmpack-test documentation built on Feb. 19, 2022, 12:25 a.m.
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Description
The class with the input for finding the next best MTD estimate with highest probability to be the MTD. The dose which has the highest probability to be the MTD among the specified doses is used as next best dose. The posterior is calculated for each iteration and the maximum dose that is not toxic (below target) is determined. The allocation criteria is calculated as the frequency of a dose being selected as MTD. The dose with the highest allocation value is selected as next best dose.
Slots
targetthe target toxicity probability
methodthe method used for calculating the allocation criteria 1=aggregate no dose safe with first dose 2=aggregate no dose safe with last dose 3=do not aggregate, but report the first dose as best next dose, in case 'no dose is safe' has the highest allocation value. This follows the idea used for the smallest distance to the target dose approach, where always a dose is recommended, even though the lowest dose estimated is above target
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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