Our novel network-based approach, CTD, “connects the dots” between metabolite perturbations observed in individual metabolomics profiles and a given disease state by calculating how connected those metabolites are in the context of a disease-specific network.
In R, install the devtools package, and install CTD by install_github(“BRL-BCM/CTD”).
Located in /vignette/CTD_Lab-Exercise.Rmd. It will take you across all the stages in the analysis pipeline, including:
Thistlethwaite, L.R. et al. (2019). CTD: a method which interprets multivariate perturbations observed in molecular profiles by identifying highly connected nodes in disease-specific co-perturbation networks. Manuscript submitted.
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