README.md

In CogDisResLab/KinaseTauScore: Tau Scores For Human Kinases

KinaseTauScore

KinaseTauScore is a data package that allows access to a curated dataset of phsophorylation profiles of human kinases on the 𝛕-protein in an Alzhemier Disease context. The data is derived from the paper High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation by Azorsa et al[^1].

Installation instructions

Get the latest stable R release from CRAN. Then install KinaseTauScore from Bioconductor using the following code:

if (!requireNamespace("BiocManager", quietly = TRUE)) {
    install.packages("BiocManager")
}

BiocManager::install("KinaseTauScore")

And the development version from GitHub with:

BiocManager::install("CogDisResLab/KinaseTauScore")

Citation

Below is the citation output from using citation('KinaseTauScore') in R. Please run this yourself to check for any updates on how to cite KinaseTauScore.

print(citation('KinaseTauScore'), bibtex = TRUE)

Please note that the KinaseTauScore was only made possible thanks to many other R and bioinformatics software authors, which are cited either in the vignettes and/or the paper(s) describing this package.

Code of Conduct

Please note that the KinaseTauScore project is released with a Contributor Code of Conduct. By contributing to this project, you agree to abide by its terms.

Development tools

• Continuous code testing is possible thanks to GitHub actions through usethis, remotes, and rcmdcheck customized to use Bioconductor’s docker containers and BiocCheck.
• Code coverage assessment is possible thanks to codecov and covr.
• The documentation website is automatically updated thanks to pkgdown.
• The code is styled automatically thanks to styler.
• The documentation is formatted thanks to devtools and roxygen2.

For more details, check the dev directory.

This package was developed using biocthis.

[^1]: Azorsa DO, Robeson RH, Frost D, et al. High-content siRNA screening of the kinome identifies kinases involved in Alzheimer’s disease-related tau hyperphosphorylation. BMC Genomics. 2010;11(1):25.

CogDisResLab/KinaseTauScore documentation built on June 16, 2022, 6:55 p.m.