# pilotHTT ##########
#' @title Annotation data
#'
#' @name pilotHTT
#'
#' @return
#' A data frame with the following (18) variables:
#' \itemize{
#' \item{\code{batch} (factor) - Batch number of image annotated by the
#' reader (10 batches in total)
#' \itemize{
#' \item \code{FDA-HTT-batch00x} - Pilot Study annotations
#' \item \code{FDA-HTT-Train00x} - Expert Panel annotations
#' }}
#' \item \code{WSI} (factor) - Whole case file name of whole slide image
#' annotated by reader
#' \item \code{caseID} (factor) - ID for region of interest. Includes WSI,
#' x position of ROI, y position of ROI, and length of ROI
#' \item{\code{readerID} (factor) - ID for each participant (profession
#' with ID number)
#' \itemize{
#' \item There are four possible professions at the front end of
#' readerID: pathologist, expert, resident, or unknown.
#' \item \code{pathologist} - board-certified pathologist
#' \item \code{expert} - member of the Expert Panel
#' \item \code{resident} - in residency
#' \item \code{unknown} - no indicated profession
#' }}
#' \item{\code{modalityID} (factor) - Platform used by viewer (caMicro,
#' pathPresenter, eeDAP, or camic-expert)
#' \itemize{
#' \item \code{caMicro} - Digital annotations collected
#' \item \code{pathPresenter} - Digital annotations collected
#' \item \code{eeDAP} - Microscope annotations collected
#' \item \code{camic-expert} - Digital Expert Panel annotations collected
#' using the caMicroscope platform
#' }}
#' \item \code{score} (num) - Percent of area occupied by lymphocytes in
#' \code{Intra-Tumoral Stroma}. (Same as \code{densityTILs}).
#' \item \code{experience} (num) - Number of years of experience for
#' pathologists. If experience == 100, experience is unknown.
#' If experience == -1, experience is not applicable for the reader.
#' \item \code{experienceResident} (num) - Number of years in residency
#' for non-pathologists. If experienceResident == 100, experience is unknown.
#' If experienceResident == -1, experience is not applicable for the reader.
#' \item \code{labelROI} (factor) - Label of region of interest
#' (Intra-Tumoral Stroma, Invasive Margin, Tumor with No Intervening
#' Stroma, other regions)
#' \item \code{VTA} (logical) - Indicates whether the region of interest
#' is appropriate for sTIL evaluation
#' \item \code{percentStroma} (num) - Percentage of tumor-associated stroma
#' in region of interest
#' \item \code{densityTILs} (num) - Percent of area occupied by lymphocytes
#' in \code{Intra-Tumoral Stroma}. (Same as \code{score})
#' \item \code{createDate} (POSIXct) - Date and time annotation was created
#' \item \code{viewerWidth} (num) - Width of image viewed in pixels
#' \item \code{viewerHeight} (num) - Height of image viewed in pixels
#' \item \code{viewerMag} (num) - Magnification setting of the viewer when
#' the data is saved
#' \item \code{task} (factor) - Version number of platform
#' \item \code{inputFileName} (chr) - File name of the input file
#' }
#'
#'
#' @description
#' This file is the aggregate of all clean data from the High-Throughput
#' Truthing project.
#' It has been cleaned of PII (names and emails) and other non-essential columns.
#'
#' @usage
#' pilotHTT
#'
#' @details
#' This data was collected from the CAmicroscope, PathPresenter, and eeDAP
#' platforms. Please refer to \href{https://github.com/DIDSR/HTT/blob/main/README.md}{https://github.com/DIDSR/HTT/blob/main/README.md}.
#' for more information about the data.
#'
#' As of 6 May 2022, this data contains 7898 observations of 18 variables.
#'
# This data is saved as rda and csv files.
#'
NULL
# scanner Information CasesHTT ##########
#' @title Scanner information for the cases used in the HTT Pilot Study
#'
#' @name scannerInformationCasesHTT
#'
#' @description This documentation includes the scanner information of
#' the HTT Pilot Study cases
#'
#' \strong{Sample information}
#'
#' The pilot study slides and images were provided by key collaborators
#' Roberto Salgado and
#' Denis Larsimont (Chair Department of Pathology, Jules Bordet Institut).
#' Support staff were
#' Ligia Craciun (Lead at Tumorbank, Dr Science) and
#' Sélim-Alex Spinette (Lab tech at Tumorbank).
#'
#' The data include slides that are either ductal or lobular
#' breast cancer cases. Differentiating between ductal and lobular
#' is often obvious. In Belgian, these are denoted as
#' CCI = carcinome canalaire (ductal) invasive and
#' CLI = carcinome lobulaire (lobular) invasive.
#'
#' The data include slides of matching (same patient)
#' biopsies or surgical resections.
#'
#' Biopsies are taken before surgery to make a diagnosis.
#'
#' The slides shared were re-cuts.
#' The original slides were imaged in 2017 and 2018.
#' We have 115 images of the slides imaged in 2017, but we don't (yet)
#' have the information to link these images to the re-cuts.
#'
#' Slides come from FFPE blocks and H&E staining. Every digital image was
#' checked.
#' If the tissue was bent, the process was repeated as needed.
#'
#' Slide 66: Two tumor nodes are described. The morphologies are similar,
#' but we cannot define exactly which node was taken at biopsy.
#'
#' \strong{Scanner information}
#'
#' Here are the details of the Nanozoomer 2.0-RS (Hamamatsu, Japan) under 40x
#' magnification single-layer
#' at the Jules Bordet Institute.
#'
#' The images were scanned on one scanner, NanoZoomer 2.0-RS C10730 series.
#' It is the high resolution and high-speed slide scanner that consists of
#' Slide–feeder, X/Y Stage, Z focus motor, illumination system, optical
#' components and TDI image sensor, this system realizes 1’ 40’’ / (20x)
#' per slide (20 mm x 20 mm scanning area). The NanoZoomer-RS system can
#' automatically load up to 6 glass slides at a 20x or 40x magnification.
#' All digital images were scanned in single layer at 40x
#' magnification.
#'
#' This scanner is equipped with a 3CCD-TDI camera which allow for
#' brightfield and fluorescence images with only one camera.
#' Resolution is 0.23um/px at 40x and 0.46um/px at 20x
#' The system is equipped with a 20x, 0.75NA objective lens, with a 2x relay lens.
#' The images are always acquired at optical 40x, we do a 2x2 binning on the
#' camera to have 20x resolution
#' This offers the advantage of keeping the depth of field of a 20x but with the
#' resolution of a 40x.
#' For fluorescence capabilities, the system can host up to 6 excitation filter,
#' 2 dichroic mirrors, and 6 emission filters.
#' Bordet is equipped to image Dapi/Fitc/Tritc/Cy3/Cy5 and equivalent.
#'
#' You can download the NDP.view software for free from the Hamamatsu website.
#'
NULL
# pilotHTT_RST ##########
#' @title Simplified annotation data of the pilot study
#'
#' @name pilotHTT_RST
#'
#' @return
#' A data frame with the following (9) variables:
#' \itemize{
#' \item{\code{batch} (factor) - Batch number of image annotated by the
#' reader (10 batches in total)
#' \itemize{
#' \item \code{FDA-HTT-batch00x} - Pilot Study annotations
#' \item \code{FDA-HTT-Train00x} - Expert Panel annotations
#' }}
#' \item \code{WSI} (factor) - Whole case file name of whole slide image
#' annotated by reader
#' \item \code{caseID} (factor) - ID for region of interest. Includes WSI,
#' x position of ROI, y position of ROI, and length of ROI
#' \item{\code{readerID} (factor) - ID for each participant (profession
#' with ID number)
#' \itemize{
#' \item There are four possible professions at the front end of
#' readerID: pathologist, expert, resident, or unknown.
#' \item \code{pathologist} - board-certified pathologist
#' \item \code{expert} - member of the Expert Panel
#' \item \code{resident} - in residency
#' \item \code{unknown} - no indicated profession
#' }}
#' \item{\code{modalityID} (factor) - Platform used by viewer (caMicro,
#' pathPresenter, eeDAP, or camic-expert)
#' \itemize{
#' \item \code{caMicro} - Digital annotations collected
#' \item \code{pathPresenter} - Digital annotations collected
#' \item \code{eeDAP} - Microscope annotations collected
#' \item \code{camic-expert} - Digital Expert Panel annotations collected
#' using the caMicroscope platform
#' }}
#' \item \code{evaluable} (logical) - Indicates whether the region of interest
#' is appropriate for sTIL evaluation
#' \item \code{densityTILs} (num) - Percent of area occupied by lymphocytes
#' in \code{Intra-Tumoral Stroma}.
#' \item \code{experience} (num) - Number of years of experience for
#' pathologists. If experience == 100, experience is unknown.
#' If experience == -1, experience is not applicable for the reader.
#' \item \code{experienceResident} (num) - Number of years in residency
#' for non-pathologists. If experienceResident == 100, experience is unknown.
#' If experienceResident == -1, experience is not applicable for the reader.
#' }
#'
#'
#' @description
#' This file is the aggregate of all clean data from the High-Throughput
#' Truthing project.
#' It has been cleaned of PII (names and emails) and other non-essential columns. This is the simplified version of `pilotHTT` meant for the FDA Regulatory Science Tool (RST) Program.
#'
#' @usage
#' pilotHTT_RST
#'
#' @details
#' This data was collected from the CAmicroscope, PathPresenter, and eeDAP
#' platforms. Please refer to \href{https://github.com/DIDSR/HTT/blob/main/README.md}{https://github.com/DIDSR/HTT/blob/main/README.md}.
#' for more information about the data.
#'
#' As of 6 May 2022, this data contains 7898 observations of 9 variables.
#'
# This data is saved as rda and csv files.
#'
NULL
# pilotImagesHTT ##########
#' @title Data frame of names of pilot study images available for download
#'
#' @name pilotImagesHTT
#'
#' @return
#' A data frame with the following (4) variables:
#' \itemize{
#' \item{\code{collection.name} name of the collection:
#' "Download-HTTpilotImages"}
#' \item{\code{collection.description} description of the collection:
#' "Download HTT pilot images."}
#' \item{\code{slide.filename} filename of the slide}
#' \item{\code{slide.name} name of the slide to appear to user}
#' }
#'
#'
#' @description
#' This data frame is used to define the collection of pilot study images that
#' are available for download. The data frame is available as an exported
#' data object and as a human-readable csv file (folder extdata). The files
#' are available for download from
#' \href{https://wolf.cci.emory.edu/camic/htt/}{https://wolf.cci.emory.edu/camic/htt/}.
#'
#' @usage
#' pilotImagesHTT
#'
#' @seealso \link{scannerInformationCasesHTT}
#'
#'
#' @examples
#' # Open and view the data object
#' pilotImagesHTT <- HTT::pilotImagesHTT
#' View(pilotImagesHTT)
#'
#'
#'
NULL
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