isobole: Creating isobolograms

In DoseResponse/drc: Analysis of Dose-Response Data

Description

'isobole' displays isobole based on EC/ED50 estimates from a log-logistic model. Additionally isoboles determined by the concentration addition model, Hewlett's model and Voelund's model can be added to the plot.

Usage

isobole(object1, object2, exchange = 1, cifactor = 2, ename = "e", 
xaxis = "100", xlab, ylab, xlim, ylim, ...)

Arguments

object1	object of class 'drc' where EC/ED50 parameters vary freely.
object2	object of class 'drc' where EC/ED50 parameters vary according to Hewlett's model.
ename	character string. The name of the EC/ED50 variable.
xaxis	character string. Is the mixture "0:100" or "100:0" on the x axis?
exchange	numeric. The exchange rate between the two substances.
cifactor	numeric. The factor to be used in the confidence intervals. Default is 2, but 1 has been used in publications.
xlab	an optional label for the x axis.
ylab	an optional label for the y axis.
xlim	a numeric vector of length two, containing the lower and upper limit for the x axis.
ylim	a numeric vector of length two, containing the lower and upper limit for the y axis.
...	Additional graphical parameters.

Details

The model fits to be supplied as first and optionally second argument are obtained using mixture and drm.

Value

No value is returned. Only used for the side effect: the isobologram shown.

Author(s)

Christian Ritz

References

Ritz, C. and Streibig, J. C. (2014) From additivity to synergism - A modelling perspective Synergy, 1, 22–29.

DoseResponse/drc documentation built on May 7, 2021, 4:55 p.m.