run.beta.mixture.model: beta mixure model to decect pCSM loci

In Gavin-Yinld/csmFinder: Find putative cell-subset specific methylation (pCSM) loci in single-cell methylomes or bulk methylomes

Description

This function is used for identifying the pCSM loci from single-cell methylomes. Briefly, a beta mixture model is utilized to divide the single-cells with hyper and hypo-methylation state into different cell subsets in a given CSM candidate region and determine the significance.

Usage

run.beta.mixture.model(candidate,thread=1,distance=0.3,adjusted_pval=0.05,cell_number=8)

Arguments

candidate	A matrix containning the candidate pCSM loci with the format produced by find.candidate.
thread	Number of thread used to be tun beta mixture model.

Value

beta.mixture.output

The matrix of beta mixture model output

References

https://github.com/Evan-Evans/Beta-Mixture-Model

Examples

#run.beta.mixture.model(candidate,thread=1,distance=0.3,adjusted_pval=0.05,cell_number=8)

Gavin-Yinld/csmFinder documentation built on Sept. 16, 2019, 3:31 p.m.