MURAT-package: MUltivariate Rare-variant Association Test
In GreenwoodLab/MURAT: MUltivariate Rare-variant Association Test

Description Details Author(s) References See Also Examples

To conduct rare-variant association test for multiple continuous traits.

The DESCRIPTION file: This package was not yet installed at build time.

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An overview of how to use the package, including the most important functions.

Jianping Sun, Karim Oualkacha, and Celia Greenwood

Maintainer: Jianping SUN <jianping.sun@mail.mcgill.ca>

Sun, J., Oualkacha, K., Forgetta1, V., Zheng, H.F., Richards, J.B., Ciampi, A., Greenwood1, C.M.T., and UK10K Consortium. (2015) A method for analyzing multiple continuous phenotypes in rare variant association studies allowing for flexible correlations in variant effects. Contidionally accepted by European Journal of Human Genetics.

MURAT

data(sample)

## three continuous traits for 500 individuals
Y <- sample$Y

## genotype data of 20 SNPs for 500 individuals
G <- sample$G

## three covairates for 500 individuals
X <- sample$X

## MURAT without weight
re <- MURAT(Y,G,X,rho=seq(0,0.9,by=0.1))

## MURAT with weight function beta(1,25)
re.w1 <- MURAT(Y,G,X,rho=seq(0,0.9,by=0.1),weight=TRUE,weight.para1=1,weight.para2=25 )

## MURAT with weight function beta(0.5,0.5)
re.w2 <- MURAT(Y,G,X,rho=seq(0,0.9,by=0.1),weight=TRUE,weight.para1=0.5,weight.para2=0.5 )