Description Details Author(s) References See Also Examples
To conduct rare-variant association test for multiple continuous traits.
The DESCRIPTION file:
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Index: This package was not yet installed at build time.
An overview of how to use the package, including the most important functions.
Jianping Sun, Karim Oualkacha, and Celia Greenwood
Maintainer: Jianping SUN <jianping.sun@mail.mcgill.ca>
Sun, J., Oualkacha, K., Forgetta1, V., Zheng, H.F., Richards, J.B., Ciampi, A., Greenwood1, C.M.T., and UK10K Consortium. (2015) A method for analyzing multiple continuous phenotypes in rare variant association studies allowing for flexible correlations in variant effects. Contidionally accepted by European Journal of Human Genetics.
MURAT
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 | data(sample)
## three continuous traits for 500 individuals
Y <- sample$Y
## genotype data of 20 SNPs for 500 individuals
G <- sample$G
## three covairates for 500 individuals
X <- sample$X
## MURAT without weight
re <- MURAT(Y,G,X,rho=seq(0,0.9,by=0.1))
## MURAT with weight function beta(1,25)
re.w1 <- MURAT(Y,G,X,rho=seq(0,0.9,by=0.1),weight=TRUE,weight.para1=1,weight.para2=25 )
## MURAT with weight function beta(0.5,0.5)
re.w2 <- MURAT(Y,G,X,rho=seq(0,0.9,by=0.1),weight=TRUE,weight.para1=0.5,weight.para2=0.5 )
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