#' @import Biostrings
#' @import splatter
#' @import IRanges
#' @import S4Vectors
#' @import logspline
#' @import Biobase
#' @import BiocGenerics
#' @importFrom stats loess model.matrix predict rbinom rnbinom rnorm runif smooth.spline
#' @importFrom utils data read.table write.table
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