translink_expected_links_obs: Calculate expected number of transmission links in a sample

In HopkinsIDD/phylosamp: Sample Size Calculations for Molecular and Phylogenetic Studies

Calculate expected number of transmission links in a sample

Description

This function calculates the expected number of observed pairs in the sample that are linked by the linkage criteria. The function requires the sensitivity and specificity of the linkage criteria, and sample size M. Assumptions about transmission and linkage (single or multiple) can be specified.

Usage

translink_expected_links_obs(
  sensitivity,
  specificity,
  rho,
  M,
  R = NULL,
  assumption = "mtml"
)

Arguments

sensitivity	scalar or vector giving the sensitivity of the linkage criteria
specificity	scalar or vector giving the specificity of the linkage criteria
rho	scalar or vector giving the proportion of the final outbreak size that is sampled
M	scalar or vector giving the number of cases sampled
R	scalar or vector giving the effective reproductive number of the pathogen (default=NULL)
assumption	a character vector indicating which assumptions about transmission and linkage criteria. Default = 'mtml'. Accepted arguments are: 'stsl' for the single-transmission single-linkage assumption. 'mtsl' for the multiple-transmission single-linkage assumption. 'mtml' for the multiple-transmission multiple-linkage assumption.

Value

scalar or vector giving the expected number of observed links in the sample

Author(s)

John Giles, Shirlee Wohl, and Justin Lessler

See Also

Other transmission linkage functions: translink_expected_links_obs_mtml(), translink_expected_links_obs_mtsl(), translink_expected_links_obs_stsl(), translink_expected_links_true_mtml(), translink_expected_links_true_mtsl(), translink_expected_links_true_stsl(), translink_expected_links_true(), translink_fdr(), translink_prob_transmit_mtml(), translink_prob_transmit_mtsl(), translink_prob_transmit_stsl(), translink_prob_transmit(), translink_samplesize(), translink_tdr()

Examples

# The simplest case: single-transmission, single-linkage, and perfect sensitivity
translink_expected_links_obs(sensitivity=1, specificity=0.9, rho=0.5, M=100, assumption='stsl')

# Multiple-transmission and imperfect sensitivity
translink_expected_links_obs(sensitivity=0.99, specificity=0.9, rho=1, M=50, R=1, assumption='mtsl')

# Small outbreak, larger sampling proportion
translink_expected_links_obs(sensitivity=0.99, specificity=0.95, rho=1, M=50, 
R=1, assumption='mtml')

# Large outbreak, small sampling proportion
translink_expected_links_obs(sensitivity=0.99, specificity=0.95, 
rho=0.05, M=1000, R=1, assumption='mtml')

HopkinsIDD/phylosamp documentation built on May 28, 2023, 3:21 a.m.