data-raw/mstate-nma/README.md

In InnovationValueInitiative/IVI-NSCLC: The IVI-NSCLC model

The posterior distributions of the parameters from the multi-state model go in this directory. The file ../params_mstate_nma.R uses this data to create the params_mstate_nma object that loads with the package.

The following notation is used to denote model type:

• fp-p0 (1st order fractional polynomial model with p1 = 0 (i.e., a Weibull model))
• fp-p00 (2nd order fractional polynomial model with p1 = p2 = 0)
• fp-p1 (1st order fractional polynomial model with p1 = 1 (i.e., a Gompertz model))
• fp-p01 (2nd order fractional polynomial model with p1 = 0 and p2 = 1)

The directory contains two types of files: (1) the parameter estimates and (2) lookup files.

Parameter estimates

The directory must contain files for the meta-analyses (models for absolute effects) and network meta-analyses (models for relative treatment effects).

Meta-analysis files

First line fixed effects meta-analyses for gefitnib:

• ma-1L-fe-gef-fp-p0.csv
• ma-1L-fe-gef-fp-p00.csv
• ma-1L-fe-gef-fp-p1.csv
• ma-1L-fe-gef-fp-p01.csv

Second line fixed effects meta-analyses for platinum-based doublet chemotherapy (PBDC):

• ma-2L-fe-pbdc-fp-p0.csv
• ma-2L-fe-pbdc-fp-p00.csv
• ma-2L-fe-pbdc-fp-p1.csv
• ma-2L-fe-pbdc-fp-p01.csv

Second line fixed effects meta-analysis for osimertinib among patients with a T790M mutation:

• ma-2L-fe-t790m-osi-fp-p0.csv
• ma-2L-fe-t790m-osi-fp-p00.csv
• ma-2L-fe-t790m-osi-fp-p1.csv
• ma-2L-fe-t790m-osi-fp-p01.csv

Network meta-analysis files

First line fixed effects network meta-analyses of treatments relative to gefitnib:

• nma-1L-fe-fp-p0.csv
• nma-1L-fe-fp-p00.csv
• nma-1L-fe-fp-p1.csv
• nma-1L-fe-fp-p01.csv

Lookup files

There are two types of lookup files.

The first type links treatments in the model to the numeric identifiers in the NMA:

• tx-lookup-1L.csv
• tx-lookup-2L.csv

The second type summarizes the parameters of the NMA in terms of the parametric and flexible parametric multi-state survival models from the hesim package (which is used to simulate the economic model):

• params-lookup-1L.xlsx
• params-lookup-2L-pbdc.xlsx
• params-lookup-2L-t790m-osi.xlsx

InnovationValueInitiative/IVI-NSCLC documentation built on July 25, 2019, 8:03 p.m.