malaria: Malaria Vaccine Trial

In JECheadle/RSOC317L: Data Sets and Supplemental Functions from David Diez's 'OpenIntro' Textbook

Description

Volunteer patients were randomized into one of two experiment groups where they would receive an experimental vaccine or a placebo. They were subsequently exposed to a drug-sensitive strain of malaria and observed to see whether they came down with an infection.

Usage

data("malaria")

Format

A data frame with 20 observations on the following 2 variables.

treatment

Whether a person was given the experimental vaccine or a placebo.

outcome

Whether the person got an infection or no infection.

Details

In this study, volunteer patients were randomized into one of two experiment groups: 14 patients received an experimental vaccine or 6 patients received a placebo vaccine. Nineteen weeks later, all 20 patients were exposed to a drug-sensitive malaria virus strain; the motivation of using a drug-sensitive strain of virus here is for ethical considerations, allowing any infections to be treated effectively.

Source

Lyke et al. 2017. PfSPZ vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection. PNAS 114(10):2711-2716. http://www.pnas.org/content/114/10/2711

Examples

data(malaria)
table(malaria)
fisher.test(table(malaria))

JECheadle/RSOC317L documentation built on May 15, 2019, 4:02 a.m.