escoSimZeroInflate: Simulate noisy observed count matirx via adding more zeros...

In JINJINT/splattermodify: Simple Simulation of Single-cell RNA Sequencing Data

Description

A logistic function is used to form a relationshop between the expression level of a gene and the probability of dropout, giving a probability for each gene in each cell. These probabilities are used in a Bernoulli distribution to decide which counts should be dropped.

Usage

escoSimZeroInflate(sim, trial, verbose)

Arguments

sim	SingleCellExperiment to add dropout to.
trial	the index of trial of simulation, all trials share the same truth but the noise is added independently for each trial
verbose	whether to print the process or not

Value

SingleCellExperiment with simulated dropout and observed counts.

JINJINT/splattermodify documentation built on May 19, 2021, 4:05 p.m.