Description Usage Arguments Details Value References Examples
Generate Litchfield and Wilcoxon's (1949) estimates in the evaluation of dose-effect experiments.
1 | LWestimate(estParams, DEdata)
|
estParams |
A numeric vector of length 2, the estimated parameters (intercept and
slope) of a straight line on the log10-probit scale, typically output
from |
DEdata |
A data frame of dose-effect data (typically, the output from
|
The input data are expected to be summarized by dose. If duplicate doses are provided, an error will be thrown.
A list of length three:
chi
= the chi-squared statistic with associated P value and
degrees of freedom,
params
= the estimated intercept and slope of the
dose-response curve on the log10 probit scale,
LWest
= the Litchfield Wilcoxon estimates of
ED50 with 95% confidence intervals and the number of records with
partial effects (npartfx) as well as other metrics used in their
step-by-step approach
(ED16, ED84, S with 95% confidence intervals, N', and fED50).
Litchfield, JT Jr. and F Wilcoxon. 1949. A simplified method of evaluating dose-effect experiments. Journal of Pharmacology and Experimental Therapeutics 96(2):99-113. [link].
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