iProMix.PermAdd.LRT: iProMix.PermAdd.LRT

In JiayiJi/iProMix: Cell-Type Specific Association Analysis for Bulk Profiling Data

Description

iProMix.PermAdd.LRT

Usage

iProMix.PermAdd.LRT(
  y,
  x,
  x_tilde = NULL,
  cov = NULL,
  pi,
  B = 1,
  CellType = 1,
  seed = NULL,
  tuningPar = 1e-08,
  diffNum = 1e-04,
  numitersNum = 200
)

Arguments

y	The quantitative measure (e.g. protein/expression) of a gene
x	The quantitative measure of anther gene (e.g. ACE2 protein levels) that we would like to know their cell-type specific dependency with Y
x_tilde	Permutated x
cov	he covariates for adjustment. Their impact on the mean value of X and Y are adjusted
pi	The proportion of cell type 1
B	The number of permutation
CellType	The cell type to be estimated. Default is 1.
seed	Seed for the permutation
tuningPar	Default is 1e-8. It is used in the embedded graphic lasso procedure for estimating correlation. A larger tuningPar can be selected if one is interested in penalized estimates
diffNum	diffNum
numitersNum	Number of Iteration

Value

A list

JiayiJi/iProMix documentation built on Dec. 18, 2021, 1:30 a.m.