Modified nadaraya-watson kernel smoother with different kernel functions for the bisulfite sequencing data, which performs smoothing on low-coverage methylation data chromosome-wise.
Bisulfite sequencing data containing genomic positions, read coverage and beta methylation values.
The smoothing window size.
The kernel function used for smoothing.
bsdata is a data.frame contains
1.) genomic location,
2.) the chromosomal position,
3.) M values, describing the number of methylated read covering a single CpG,
4.) Cov values (read coverage), describing the total number of reads covering a single CpG,
5.) meth values, describing the beta estimated methylation values computed by M/Cov.
The estimated DNA methylation value for a single sample.
Junfang Chen, Pavlo Lutsik and Ruslan Akulenko.
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