Description Usage Arguments Details Value Author(s) Examples
Modified nadaraya-watson kernel smoother with different kernel functions for the bisulfite sequencing data, which performs smoothing on low-coverage methylation data chromosome-wise.
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bsdata |
Bisulfite sequencing data containing genomic positions, read coverage and beta methylation values. |
h |
The smoothing window size. |
kernel |
The kernel function used for smoothing. |
bsdata
is a data.frame contains 1.)
genomic location, 2.)
the chromosomal position,
3.)
M values, describing the number of methylated read covering a single CpG,
4.)
Cov values (read coverage), describing the total number of reads covering a single CpG,
5.)
meth values, describing the beta estimated methylation values computed by M/Cov.
The estimated DNA methylation value for a single sample.
Junfang Chen, Pavlo Lutsik and Ruslan Akulenko.
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