Description Usage Arguments Details Value Author(s) References Examples
A function evaluting a conditional mean (CM) of being affected of the disease using family history
1 | cal_rp(fam, h, prev, target)
|
fam |
Input file in FAM format of PLINK. Target individuals and their relatives should be all included in the FAM file. |
h |
Heritability of the disease |
prev |
Prevalence of the disease (should be specified according to the population) |
target |
Target individuals whose conditional mean being evaluated. This should be a index vector in the samples in the FAM file |
Please see the reference paper.
res_rp_I |
a matrix including IID and CM |
Jungsoo Gim
Jungsoo Gim, 2017, Genetics, "Incorporating family disease history in risk prediction models with large-scale genetic data substantially reduces unexplained variation."
1 |
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