Kange2014/dGSMEF: A dynamic genome-scale modelling of E. coli fermentation

A dynamic genome-scale modelling of E. coli fermentation including batch, fed-batch and induction phases for recombinant protein expression. It's implemented with static optimization approach (SOA). First, the simulation time is divided into small periods which are assumed to be in quasi-steady state; Second, for every time step, an flux balance analysis (FBA) problem is solved and the fluxes are integrated over the time period and extracellular concentrations are calculated, accordingly.

install.packages("remotes")
remotes::install_github("Kange2014/dGSMEF")