View source: R/NovershternHematopoieticData.R
NovershternHematopoieticData | R Documentation |
Download and cache the normalized expression values of 211 bulk human microarray samples of sorted hematopoietic cell populations that can be found in GSE24759.
NovershternHematopoieticData(
ensembl = FALSE,
cell.ont = c("all", "nonna", "none"),
legacy = FALSE
)
ensembl |
Logical scalar indicating whether to convert row names to Ensembl IDs. Genes without a mapping to a non-duplicated Ensembl ID are discarded. |
cell.ont |
String specifying whether Cell Ontology terms should be included in the |
legacy |
Logical scalar indicating whether to pull data from ExperimentHub. By default, we use data from the gypsum backend. |
The dataset contains 211 human microarray samples annotated to 16 main cell types ("label.main"
):
Basophils
B cells
CMPs
Dendritic cells
Eosinophils
Erythroid cells
GMPS
Granulocytes
HSCs
Megakaryocytes
MEPs
Monocytes
NK cells
NK T cells
CD8+ T cells
CD4+ T cells
Samples were additionally annotated to 38 fine cell types ("label.fine"
):
Basophils
Naive B cells
Mature B cells class able to switch
Mature B cells
Mature B cells class switched
Common myeloid progenitors
Plasmacytoid Dendritic Cells
Myeloid Dendritic Cells
Eosinophils
Erythroid_CD34+ CD71+ GlyA-
Erythroid_CD34- CD71+ GlyA-
Erythroid_CD34- CD71+ GlyA+
Erythroid_CD34- CD71lo GlyA+
Erythroid_CD34- CD71- GlyA+
Granulocyte/monocyte progenitors
Colony Forming Unit-Granulocytes
Granulocyte (Neutrophilic Metamyelocytes)
Granulocyte (Neutrophils)
Hematopoietic stem cells_CD133+ CD34dim
Hematopoietic stem cell_CD38- CD34+
Colony Forming Unit-Megakaryocytic
Megakaryocytes
Megakaryocyte/erythroid progenitors
Colony Forming Unit-Monocytes
Monocytes
Mature NK cells_CD56- CD16+ CD3-
Mature NK cells_CD56+ CD16+ CD3-
Mature NK cells_CD56- CD16- CD3-
NK T cells
Early B cells
Pro B cells
CD8+ Effector Memory RA
Naive CD8+ T cells
CD8+ Effector Memory
CD8+ Central Memory
Naive CD4+ T cells
CD4+ Effector Memory
CD4+ Central Memory
The subtypes have also been mapped to the Cell Ontology ("label.ont"
,
if cell.ont
is not "none"
), which can be used for further programmatic
queries.
A SummarizedExperiment object with a "logcounts"
assay
containing the log-normalized expression values, along with cell type labels in the
colData
.
Jared Andrews
Novershtern N et al. (2011). Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell 144, 296-309.
ref.se <- NovershternHematopoieticData()
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