pkpopini: Compute initial population PK parameters

In MarcLavielle/Rsmlx: R Speaks 'Monolix'

Compute initial population PK parameters

Description

Use the pooled PK data to derive population PK parameters for a "standard" PK model (i.e. a model of the Monolix PK library). The structural model is automatically defined using the names of the PK parameters. Allowed names are: 'Tlag', 'Mtt', 'Ktr', 'ka', 'Tk0', 'V', 'V1', 'V2', 'V3', 'Q', 'Q2', 'Q3', 'Cl', 'k', 'k12', 'k21', 'k13', 'k31', 'Vm', 'Km'.

Usage

pkpopini(
  data = NULL,
  project = NULL,
  parameter = NULL,
  new.project = NULL,
  new.dir = NULL,
  par.ini = NULL
)

Arguments

data	a list with fields dataFile: path to a formatted data file headerTypes: a vector of strings
project	a Monolix project
parameter	a vector of strings (names of the PK parameters)
new.project	name of the new Monolix project (a default name is created if not provided)
new.dir	name of the directory where the created files are stored (default is the current working directory) )
par.ini	a vector of PK parameter values

Details

A Monolix project is then automatically created using these values as initial population parameters.

See https://monolix.lixoft.com/rsmlx/pkpopini/ for more details.

Value

A list of results

Examples

## Not run: 
# Create in the working directory a Monolix project for a 1 cpt model with 
# lag time, 0 order absorption and linear elimination
warf.ini1 <- pkpopini(data=warfarin, param=c("Tlag", "Tk0", "V", "Cl")) 

# Create in directory 'warfarin' a Monolix project called 'warfPK2.mlxtran' 
# for a 2 cpt model with 1st order absorption and nonlinear elimination
warf.ini3 <- pkpopini(data=warfarin, param=c("ka", "V", "k12", "k21", "Vm", "Km"), 
                      new.dir="warfarin", new.project="warfPK2.mlxtran") 

## End(Not run)

MarcLavielle/Rsmlx documentation built on March 1, 2024, 2:01 a.m.