rmst_two_arm: Calculate RMST difference

In Merck/simtrial: Clinical Trial Simulation

Calculate RMST difference

Description

Calculate RMST difference

Usage

rmst_two_arm(
  time_var,
  event_var,
  group_var,
  trunc_time,
  reference = sort(unique(group_var))[1],
  alpha = 0.05
)

Arguments

time_var	A numeric vector of follow up time.
event_var	A numeric or integer vector of the status indicator; 0=alive 1=event.
group_var	A vector of treatment groups.
trunc_time	A numeric vector of pre-defined cut-off time point(s).
reference	Group name of reference group for RMST comparison. Default is the first group name by alphabetical order.
alpha	A numeric value of the significant level for RMST confidence interval. Default is 0.05.

Value

A list of 2 data frames of RMST calculations:

• rmst_per_arm: the calculation results per group.

• rmst_diff: the calculation results of RMST differences.

Examples

data(ex1_delayed_effect)
with(
  ex1_delayed_effect,
  simtrial:::rmst_two_arm(
    time_var = month,
    event_var = evntd,
    group_var = trt,
    trunc_time = 6,
    reference = "0",
    alpha = 0.05
  )
)

Merck/simtrial documentation built on April 14, 2025, 5:37 a.m.