The ADARR R package is contains functions for annotating results from the Sprint RNA editing pipeline.
https://github.com/jumphone/SPRINT
This annotates each site with the gene identities, genomic regions, and repeat elements overlapping with the sites. This can be integrated with pre-exisiting command line pipelines.
Using this package requires the GenomicRanges Bioconductor package. This can be obtained as follows.
if (!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("GenomicRanges")
This R package can be installed via Github as follows.
install.packages("devtools")
library(devtools)
devtools::install_github("MilesLab/ADARR")
Of note, this package requires alignment to the hg38 human genome. Other annotations may be available in the future.
Documentation for the functions of ADARR are provided here.
https://github.com/MilesLab/ADARR/raw/main/ADARR_0.1.0.pdf
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