LEAP: Patient level data on the randomized trial Learning Early...

In OpenIntroStat/openintro: Datasets and Supplemental Functions from 'OpenIntro' Textbooks and Labs

Patient level data on the randomized trial Learning Early About Peanut (LEAP) allergies.

Description

This study examined whether early exposure to peanuts increased tolerance and protection from developing a peanut allergy in children who are allergic to eggs or who have severe eczema. Participants between 4 and 11 months old were randomized to either avoid versus consume peanut based products during the first three years of life. The longer title of the study is Induction of Tolerance Through Early Introduction of Peanut in High-Risk Children and can be found in https://clinicaltrials.gov/ as study NCT00329784.

Usage

LEAP

Format

A data frame with 640 rows and 7 columns

participant.ID

Character vector, unique identifier for each participant.

stratum

Factor, outcome of a skin prick test (SPT) conducted before randomization, with levels SPT-Negative, participant shows no evidence of peanut allergy, and SPT-Positive, evidence of a peanut allergy. Participants were randomized separately within each stratum. The primary analysis of the study is typically restricted to the SPT-Negative group.

treatment.group

Factor, randomized assignment for each participant, with levels Peanut Avoidance and Peanut Consumption

.

age.months

Participant age in months at randomization.

sex

Factor, sex of participant with levels Female and Male

primary.ethnicity

Factor variable with levels Asian, Black, Other, Mixed, and White.

overall.V60.outcome

Factor, indicating whether after 5 years, the participant had an allergic reaction in the OFC, with levels for having a reaction to a peanut based oral food challenge, with levels (FAIL OFC) (allergic reaction), (PASS OFC) (no allergic reaction)

Details

More variables are available at the site in the source.

Source

These data are a subset of variables from the file ADSTART0_2015-03-03_14-20-10.txt, available by downloading study files from https://www.immport.org/shared/study/SDY660

References

Du Toit, George, et al. "Randomized trial of peanut consumption in infants at risk for peanut allergy." New England Journal of Medicine 372.9 (2015): 803-813. doi 10.1056/nejmoa1414850

OpenIntroStat/openintro documentation built on Jan. 2, 2025, 6:15 a.m.