malaria: Malaria Vaccine Trial

In OpenIntroStat/openintro: Datasets and Supplemental Functions from 'OpenIntro' Textbooks and Labs

Malaria Vaccine Trial

Description

Volunteer patients were randomized into one of two experiment groups where they would receive an experimental vaccine or a placebo. They were subsequently exposed to a drug-sensitive strain of malaria and observed to see whether they came down with an infection.

Usage

malaria

Format

A data frame with 20 observations on the following 2 variables.

treatment

Whether a person was given the experimental vaccine or a placebo.

outcome

Whether the person got an infection or ⁠no infection⁠.

Details

In this study, volunteer patients were randomized into one of two experiment groups: 14 patients received an experimental vaccine or 6 patients received a placebo vaccine. Nineteen weeks later, all 20 patients were exposed to a drug-sensitive malaria virus strain; the motivation of using a drug-sensitive strain of virus here is for ethical considerations, allowing any infections to be treated effectively.

Source

Lyke et al. 2017. PfSPZ vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection. PNAS 114(10):2711-2716. \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1073/pnas.1615324114")}.

Examples

library(dplyr)

# Calculate conditional probabilities of infection after vaccine/placebo
malaria |>
  count(treatment, outcome) |>
  group_by(treatment) |>
  mutate(prop = n / sum(n))

# Fisher's exact text
fisher.test(table(malaria))

OpenIntroStat/openintro documentation built on June 4, 2024, 4:19 a.m.