peccary_NCA: Basic Non Compartimental Analysis

In Peccary-PMX/PeccAnalysis: Analyse PK/PD dataset

Basic Non Compartimental Analysis

Description

peccary_NCA compute basic NCA analysis (no extrapolation)

Usage

peccary_NCA(
  dataset,
  timecol,
  obscol,
  ...,
  evidcol = NULL,
  BLQcol = NULL,
  auc_0_X = 0,
  filter = "",
  keepcov = T,
  plotQC = F,
  outputExpr = F,
  IVbackextr = F,
  add_Obs0_Time0 = F,
  nIVback = 2
)

Arguments

dataset	Dataset to analyze
timecol	The name (unquoted) of the time column. Mandatory.
obscol	The name (unquoted) of the observation column. Mandatory.
...	All the names (unquoted) of the grouping column (ID, YTYPE, nAdmin, any covariate....).
evidcol	The name (unquoted) of the evid column. Optional. Only line with evidcol = 0 will be kept
BLQcol	The name (unquoted) of the evid column. Optional. BLQ values are replaced by 0.
auc_0_X	Numeric input. Compute AUC from time 0 to time auc_0_X
filter	Optional filter to be applied on the dataset prior to NCA computation.
keepcov	Boolean. If true (default), use pecc_search_cov to keep automatically all covariates
plotQC	Boolean. If T, create plots to control the output (default = F)
outputExpr	Boolean. If F (default) returns directly NCA results. If T, return R code instead.
IVbackextr	Boolean. If T, compute C0 based on the first nIVback points.
add_Obs0_Time0	Boolean. If T, add observation 0 at times 0 for all patients. Usefull in case of non intravscular administration(default = F)
nIVback	Numeric input. Number of point used for the backextrapolation. Default 2 as in PKAnalix

Author(s)

Thibaud Derippe ([e-mail])

Examples

# To get the Peccary-independant code, add outputExpr = T

Peccary-PMX/PeccAnalysis documentation built on July 7, 2022, 5:27 a.m.