Man pages for PeterDeWeirdt/intactr
Detect Interactions from CRISPR Combinatorial Screens
| alphabetize_combos | alphabetize gene combinations |
| apop_combo_lfcs | log-fold changes for an apoptotic combinatorial screen |
| average_gene_scores | Summarize gene combinations by calculating the average lfc... |
| calculate_anchor_residuals | Calculate genetic interaction scores by treating each guide... |
| calculate_base_lfcs | Take the median lfc for each guide paired with controls to... |
| check_input | Checks input for correct column names |
| cluster_order | return order tibble by hierarchical clustering |
| get_combo_lfcs | Average lfc for gene combinations |
| get_fdrs | Calculate an empircal fdr combo z-scores |
| get_gene_lfcs | get the lfcs for each gene |
| get_guide_residuals | Calculate the residual for each guide |
| get_one_guide_z | Calculate the z-score of the residual of each guide pair |
| get_two_gene_z | Calculate the gene level z-score from the guide level... |
| group_controls | Groups together controls into pseudogenes |
| hello | Hello, World! |
| join_base_lfcs | Join base lfcs for each guide in a construct |
| plot_combo | plot box plots with all constructs for a given combination |
| plot_combo_residuals | Visualize the residual plot for all of the guides for a pair... |
| plot_hit_network | create a network of top hits with genes as nodes and scores... |
| plot_score_heatmap | plot heatmap of combo scores |
| preprocess_lfcs | Check input, group combos and tidy lfcs |
| reverse_genes | reverse all gene scores, so we can group by the first gene... |
| reverse_guides | reverse all guide scores, so we can group by the first gene... |
| theme_intactr | universal theme for intactr plots |
| tidy_input | pivot input longer |
