run.sim: A Unified Platform for Comprehensive Evaluation of Phase I...

In RemyMacDonald/UnifiedDesign: A Unified Platform for Comprehensive Evaluation of Phase I Clinical Trial Designs

Description

This is a description

Usage

run.sim(
  prob,
  nSim = 10,
  dose = 3^{     0:(length(prob) - 1) },
  ttl = 0.3,
  n = 60,
  m = 3,
  Max_FoldChange = 3,
  epsilon1 = 0.05,
  epsilon2 = 0.05,
  pod1 = 0.95,
  alpha = 1,
  beta = 1,
  cohort.size = c(3, 5, 8, 10),
  theta = 0.25,
  alpha1 = 1,
  beta1 = 4
)

Arguments

prob	Vector of true DLT rates
nSim	Number of studies to simulate
dose	Dose levels of recruited patients
ttl	Target toxicity level
n	The maximum sample size of the trial
m	The cohort size
Max_FoldChange	Maximum fold change
pod1	Eliminate the current dose and higher if the posterior probability of exceeding the target toxicity level exceeds this value
alpha	Prior shape1 parameter
beta	Prior shape2 parameter
cohort.size	Vector of cohort sizes
theta	Safety threshold for cohort-sequence design
alpha1	Prior shape1 parameter for cohort-sequence design
beta1	Prior shape2 parameter for cohort-sequence design

Value

run.sim( ) returns a list of simulation results

Examples

run.sim(prob=c(0.21, 0.30, 0.37, 0.43, 0.48, 0.52, 0.56, 0.61, 0.64, 0.66))

RemyMacDonald/UnifiedDesign documentation built on Dec. 18, 2021, 9:57 a.m.