plethem-package: Population Life Course Exposure to Health Effects Modeling

In ScitoVation/plethem: Population Life Course Exposure to Health Effects Modeling

Description

Functions, data and user interfaces for performing physiologically based pharmacokinetic ('PBPK') modeling, in-vitro-to-in-vivo Extrapolation ('IVIVE') and exposure estimation. Also contains user interfaces to run models from the 'httk' package. Taken together these provide an easy to use and powerful modeling tool that can be used for all steps along the source-to-outcome continuum.All the analysis tools in the package are run as interactive applications. Check package help for more information. Refer to the manuscript 'Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling' <doi: 10.1016/j.comtox.2019.100115> for more information on the models and algorithms used in the package. More information on PBPK modeling itself can be found in the book 'Physiologically Based Pharmacokinetic Modeling: Science and Applications' by Reddy et al <doi:10.1002/0471478768>.

Author(s)

Jeremy Fitzpatrick, Kevin Bronson, C. Eric Hack, Patrick McMullen, and Salil Pendse

References

Pendse, S.N.; Efremenko, A.; Hack, C.E.; Moreau, M.; Mallick, P.; Dzierlenga, M.; Nicolas, C.I.; Yoon, M.; Clewell, H.J.; McMullen, P.D. Population Life-course Exposure to Health Effects Model (PLETHEM): An R package for PBPK modeling. Computational Toxicology. 2020 13:1-10

Examples

  ## run the interactive interface for foward dosimetry
  interactivePBPK(name='rapidPBPK')

ScitoVation/plethem documentation built on Oct. 1, 2020, 3:37 a.m.