scale_cellular_enzymatic: Scale clearance by age when both cellular and enzymatic...

In ScitoVation/plethem: Population Life Course Exposure to Health Effects Modeling

Description

This function is used internally to calculate age specific metabolism using the IVIVE gadget. It needs both cellular and enzymatic clearance at atleast one age, the reference age, to extrapolate to values at other ages.

Usage

scale_cellular_enzymatic(
  out_ages,
  tot_scaled_hepcl,
  tot_scaled_recomcl,
  cypDb,
  cypCl,
  gender
)

Arguments

out_ages	Ages for which the clearance needs to be calculated including reference age
tot_scaled_hepcl	Total cellular clearance at reference age in L/h/kg Liver
tot_scaled_recomcl	Total Recombinant enzyme clearance at reference age in L/h/kg Liver
cypDb	Dataframe containing cyp datasets to scale measured clearance values from in-vitro to in-vivo
cypCl	Datafarame containing measured invitro enzymatic clearance.
gender	Gender either "M" for male or "F" for female

Value

List with individual enzyme and total clearance at all ages.

ScitoVation/plethem documentation built on Oct. 1, 2020, 3:37 a.m.