scale_cellular_enzymatic: Scale clearance by age when both cellular and enzymatic...

Description Usage Arguments Value

View source: R/IVIVEScaling.R

Description

This function is used internally to calculate age specific metabolism using the IVIVE gadget. It needs both cellular and enzymatic clearance at atleast one age, the reference age, to extrapolate to values at other ages.

Usage

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scale_cellular_enzymatic(out_ages, tot_scaled_hepcl, tot_scaled_recomcl,
  cypDb, cypCl, gender)

Arguments

out_ages

Ages for which the clearance needs to be calculated including reference age

tot_scaled_hepcl

Total cellular clearance at reference age in L/h/kg Liver

tot_scaled_recomcl

Total Recombinant enzyme clearance at reference age in L/h/kg Liver

cypDb

Dataframe containing cyp datasets to scale measured clearance values from in-vitro to in-vivo

cypCl

Datafarame containing measured invitro enzymatic clearance.

gender

Gender either "M" for male or "F" for female

Value

List with individual enzyme and total clearance at all ages.


ScitoVation/plethem documentation built on Aug. 23, 2019, 2:13 p.m.