FPS: Calculate of ferroptosis score

In Yelab2020/FPSOmics: Ferroptosis Score and associated multi-Omics

Calculate of ferroptosis score

Description

We firstly calculate enrichment score (ES) of ferroptosis-promote genes(pro-FRGs) and ferroptosis-inhibit genes(anti-FRGs) using single sample gene set enrichment analysis (ssGSEA), then ferroptosis score was defined by the ES of pro-FRGs minus anti-FRGs.

Usage

FPS(input_exp_data)

Arguments

input_exp_data

expression matrix (rownames of the variable must be gene symbol, each column is a sample)

Value

data.frame of ferroptosis score, column of pro is pro-ferroptosis score, column of anti is anti-ferroptosis score, column of FPS is Ferroptosis score, column of barcode is samples, column of myclusters is high and low group divided by median ferroptosis score

Examples

data(m1_input_mRNA,package='FPSOmics')
FPS_score=FPS(m1_input_mRNA)

Yelab2020/FPSOmics documentation built on May 14, 2022, 8:59 p.m.