combine_ps: Combine p-values

In adamwaring/ClusterBurden: Rare variant association utilising burden and positional information.

Description

Combine p-values using chi-squared or z-score combination method.

Usage

combine_ps(burden_pval, position_pval, method = "chisq")

Arguments

burden_pval	P-value from a burden test such as Fisher's exact-test
position_pval	P-value from a position test such as Chi-squared two-sample test
method	Method to combine p-values. "chisq" for Fisher's method. "z-score" for Stouffer's method.

Details

This is a method to combine p-values using either Fisher's method or Stouffer's method.

Usage is simple however you must first calculate burden and position p-values. Burden p-values can be calculated using ClusterBurden::burden_test() or any other RVAT that does not use positional information Position p-values can be calculated using ClusterBurden::BIN_test() or any other position test that is not sensitive to burden

If any p-values are zero then the function returns zero.

The functions have been adapted from the R package metap but re-written here to reduce dependencies.

Value

Returns a single unnamed p-value of type num

Author(s)

Adam Waring - [e-mail]

adamwaring/ClusterBurden documentation built on July 29, 2020, 9:50 p.m.