aet21/EpiSCORE: Epigenetic cell-type deconvolution with Single-Cell Omic References
EpiSCORE is an R package aimed at performing cell-type deconvolution of DNA methylation data from solid tissues. With EpiSCORE you can: (i) construct a tissue specific DNA methylation (DNAm) reference matrix (this is done by imputation from a corresponding tissue specific scRNAseq atlas), (ii) estimate fractions for the main cell types in a bulk-tissue sample for which a genome-wide DNAm profile exists. (iii) in conjunction with our EpiDISH package you can then also infer cell-type specific DNAm changes. In this package we also provide the first installment of a DNAm-atlas containing DNAm reference matrices for 13 tissue-types, encompassing 42 cell-types.
Getting started
Browse package contents
Package details |
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| Author | Andrew E. Teschendorff <andrew@sinh.ac.cn> |
| Maintainer | Andrew E. Teschendorff <andrew@sinh.ac.cn> |
| License | GPL-2 |
| Version | 0.9.6 |
| URL | https://github.com/aet21/EpiSCORE |
| Package repository | View on GitHub |
| Installation |
Install the latest version of this package by entering the following in R:
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