aet21/EpiSCORE: Epigenetic cell-type deconvolution with Single-Cell Omic References

EpiSCORE is an R package to construct a tissue specific DNA methylation (DNAm) reference matrix starting out from a corresponding tissue specific scRNAseq atlas. With the DNAm reference matrix one can then estimate fractions for the main cell types present in the reference matrix in a bulk-tissue sample for which a genome-wide DNAm profile exists. In this package we provide the first installment of a DNAm-atlas containing DNAm reference matrices for 13 tissue-types. In addition, the package allows inference of cell type specific differential DNAm in the context of a general epigenome-wide association study.

Getting started

Package details

AuthorAndrew E. Teschendorff <andrew@picb.ac.cn>
MaintainerAndrew E. Teschendorff <andrew@picb.ac.cn>
LicenseGPL-2
Version0.9.5
URL https://github.com/aet21/EpiSCORE
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("remotes")
remotes::install_github("aet21/EpiSCORE")
aet21/EpiSCORE documentation built on June 26, 2022, 5:50 p.m.