EpiSCORE is an R package to construct a tissue specific DNA methylation (DNAm) reference matrix starting out from a corresponding tissue specific scRNAseq atlas. With the DNAm reference matrix one can then estimate fractions for the main cell types present in the reference matrix in a bulk-tissue sample for which a genome-wide DNAm profile exists. In this package we provide the first installment of a DNAm-atlas containing DNAm reference matrices for 13 tissue-types. In addition, the package allows inference of cell type specific differential DNAm in the context of a general epigenome-wide association study.
Package details |
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Author | Andrew E. Teschendorff <andrew@picb.ac.cn> |
Maintainer | Andrew E. Teschendorff <andrew@picb.ac.cn> |
License | GPL-2 |
Version | 0.9.5 |
URL | https://github.com/aet21/EpiSCORE |
Package repository | View on GitHub |
Installation |
Install the latest version of this package by entering the following in R:
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