get.obs.geno: Adds some error to genotype data

In agaye/ESPRESSO.ExE: Power Analysis and Sample Size Calculation for a environment-environment interaction model

Description

Simulates errors and adds it to the true data to obtain observed data. The alleles simulated by the function sim.geno.data are randomly misclassified and used to form new genotypes that represent the observed genotypes.

Usage

get.obs.geno(allele.A = NULL, allele.B = NULL, geno.model = NULL,
  MAF = NULL, geno.error = NULL)

Arguments

allele.A	Allele A
allele.B	Allele B
geno.model	genetic model; binary=0 and additive=1
MAF	minor allele frequency of the SNP (in ESPRESSO this is the frequency of the 'at risk' allele)
geno.error	a vector with two values, the misclassififcation rates related to the sensitivity and specificity of the assessment of the alleles, i.e. 1-sensitivity and 1-specificity

Value

a dataframe that contains the below data: observed.genotype observed genotypes observed.allele.A observed A alleles observed.allele.B observed B alleles

Author(s)

Gaye A.

agaye/ESPRESSO.ExE documentation built on May 10, 2019, 7:30 a.m.