This R package models the relationship between dose levels and responses in pharmacological and toxicological experiments using the 4 Parameter Logistic (4PL) model. Traditional R packages on doseresponse modelling such as drc and nplr often draw errors due to convergence failure especially when data have outliers or nonlogistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical theory. As remedies to convergence failure problems, this R package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes.
Package details 


Maintainer  
License  GPL 
Version  1.0.0 
URL  https://github.com/ahwbest/dr4pl 
Package repository  View on GitHub 
Installation 
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