This R package models the relationship between dose levels and responses in pharmacological and toxicological experiments using the 4 Parameter Logistic (4PL) model. Traditional R packages on dose-response modelling such as drc and nplr often draw errors due to convergence failure especially when data have outliers or non-logistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical theory. As remedies to convergence failure problems, this R package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes.
Package details |
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Maintainer | |
License | GPL |
Version | 1.0.0 |
URL | https://github.com/ahwbest/dr4pl |
Package repository | View on GitHub |
Installation |
Install the latest version of this package by entering the following in R:
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