This package provides a Bayesian modelling framework for MPRA data. Rather than using t-tests on derived quantities (i.e. log(mRNA/DNA) activities) or fitting linear models, this package employs a negative binomial model on the raw MPRA barcode counts. Implemented in Stan, it provides a posterior distribution on the transcriptional shift of variants. It bases the prior distribution on variant model parameters on empirical estimates based on genomic-annotation-based similarity.
Package details |
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Maintainer | |
License | GPL (>= 2) |
Version | 0.0.0.9000 |
Package repository | View on GitHub |
Installation |
Install the latest version of this package by entering the following in R:
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