compute_cim_phewas: compute_cim_phewas

Description Usage Arguments

Description

computes the PheWAS analysis on ICD codes

Usage

1
2
3
compute_cim_phewas(cim, patients, cim_min_occur = 5, zero_controls_add = 2,
  with_boot = FALSE, perm = 1000, boot_all = FALSE,
  fdr_threshold = 0.05, progress = NULL, cores = 1)

Arguments

cim

cim data.frame from the 'get_data_from_num' function

patients

patients data.frame from the 'get_data_from_num' function

cim_min_occur

integer. minimum number of occurrences of the biological test result in the dataset to be analyzed

zero_controls_add

integer. number of simulated patients to add to the control group for a given if there is no occurrence of this concept in the control group. This trick allows to compute a pvalue in this situation.

with_boot

logical. perform a bootstrap on the results

perm

integer. number of permutations for the bootstrap

boot_all

logical. perform a bootstrap on all the results or only on the results with FDR corrected p.value < fdr_threshold

fdr_threshold

maximum FDR corrected p.value to perform the bootstrap

progress

progress bar object


aneuraz/multimodalPhewas documentation built on May 29, 2019, 4:50 p.m.