Description Usage Arguments Details Value References See Also Examples
Remove bias from an expression matrix along specified components.
1 | biasCorrection(x, metrics)
|
x |
An |
metrics |
A data frame with bias metrics for each array. |
Each individual gene is fit to a multivariate linear model with metrics
as the independent variables.
The residuals from the fit are retained as the “bias corrected” values.
Either an ExpressionSet
or a matrix (corresponding to the class of x
).
Eklund, A.C. and Szallasi, Z. (2008) Correction of technical bias in clinical microarray data improves concordance with known biological information. Genome Biology, 9:R26.
1 2 3 4 5 6 7 | ## For testing/example purposes only:
## This data set has too few samples to do meaningful bias correction
library(affydata)
data(Dilution)
eset <- rma(Dilution)
bm <- getBiasMetrics(Dilution, eset)
esetCorrected <- biasCorrection(eset, bm)
|
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