Description Usage Arguments Value References
We compute the significant SNPs for the adaptive test (AZ) based on weighting the SZ and SZ2 tests.
1 | Lamatz(Z, Sig, rho = 0:10/10, alpha = 5e-08)
|
Z |
matrix of summary Z-statistics (SNPs by traits) |
Sig |
the estimated marginal trait correlation matrix |
rho |
weights for the SZ |
alpha |
desired genome-wide significance level (default to 5E-8) |
significant SNP list for AZ
Guo,B. and Wu,B. (2018) Integrate multiple traits to detect novel disease-gene association using GWAS summary data with an adaptive test approach. Bioinformatics, under revision.
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