MTA.gee: GEE association test of multiple quantitative traits

Description Usage Arguments Value References

Description

An efficient implementation of genome-wide association test of multiple quantitative traits using GEE score tests.

Usage

1
MTA.gee(obj, G)

Arguments

obj

fitted null model from MLM.null

G

genotype vector

Value

p.value

three association p-values: an ombinus m-DF chi-square test; two 1-DF chi-square tests assuming common effect or common scaled effect (see ref)

U,V

score vector (U) and its asymptotic covariance matrix (V)

References

He,Q., Avery,C.L. and Lin,D.Y. (2013) A general framework for association tests with multivariate traits in large-scale genomics studies. Genetic Epidemiology, 37 (8), 759–767.

Wu,B. and Pankow,J.S. (2017) Fast and accurate genome-wide association test of multiple quantitative traits. tech report.


baolinwu/MTAR documentation built on May 14, 2019, 6:03 a.m.