haiti_enterics: dataset: Leogane, Haiti enteric pathogen multiplex antibody...

In ben-arnold/tmleAb: Targeted maximum likelihood estimation for antibody measurements

Description

IgG antibody responses to protozoan, bacterial, and viral enteric pathogens measured with a multiplex bead assay in sample sets collected from 142 children ages 0-12 years in Leogane, Haiti. Children were enrolled between the ages of 1 month and 6 years on a rolling basis from 1991-1999 to monitor lymphatic filariasis, and the selection of samples from the Haiti cohort has been described in detail. Children were measured between 1 and 9 times. All antibody levels were measured on the Luminex platform and are in units of median flourescence intensity minus background (MFI-bg). A comparable dataset (and run with the same bead set) for children in the USA is also included in the package: usa_enterics.

Usage

data(haiti_enterics)

Format

A data frame with 771 observations and 12 variables.

id

individual ID

sampleid

specimen ID

agem

age in months

agey

age in years

cp17

response (MFI-bg) to Cryptosporidium parvum recombinant 17-kDa antigen

cp23

response (MFI-bg) to Cryptosporidium parvum recombinant 27-kDa antigen

vsp5

response (MFI-bg) to the VSP-5 fragment of Giardia intestinalis variant-specific surface protein 42e

leca

response (MFI-bg) to Entamoeba histolytica lectin adhesion molecule (LecA)

etec

response (MFI-bg) to Enterotoxigenic Escherichia coli (ETEC) heat labile toxin β subunit

salb

response (MFI-bg) to lipopolysaccharide (LPS) from Salmonella enterica serotype Typhimurium (Group B)

norogii

response (MFI-bg) to purified recombinant norovirus GII.4 New Orleans virus-like particles from a baculovirus expression system

norogi

response (MFI-bg) to purified recombinant norovirus GI.4 virus-like particles from a baculovirus expression system

References

K. L. Hamlin et al., Longitudinal monitoring of the development of antifilarial antibodies and acquisition of Wuchereria bancrofti in a highly endemic area of Haiti. PLoS Negl. Trop. Dis. 6, e1941 (2012).

D. M. Moss et al., Longitudinal Evaluation of Enteric Protozoa in Haitian Children by Stool Exam and Multiplex Serologic Assay. The American Journal of Tropical Medicine and Hygiene 90 (4): 653–60 (2014).

D. M. Moss, J. M. Montgomery, S. V. Newland, J. W. Priest, P. J. Lammie, Detection of cryptosporidium antibodies in sera and oral fluids using multiplex bead assay. J. Parasitol. 90, 397–404 (2004).

J. W. Priest et al., Multiplex assay detection of immunoglobulin G antibodies that recognize Giardia intestinalis and Cryptosporidium parvum antigens. Clin. Vaccine Immunol. 17, 1695–1707 (2010).

E. Houpt et al., Prevention of intestinal amebiasis by vaccination with the Entamoeba histolytica Gal/GalNac lectin. Vaccine. 22, 611–617 (2004).

J. Flores et al., Enterotoxigenic Escherichia coli Heat-Labile Toxin Seroconversion in US Travelers to Mexico. J. Travel Med. 15, 156–161 (2008).

M. A. Strid, T. Dalby, K. Mølbak, K. A. Krogfelt, Kinetics of the human antibody response against Salmonella enterica Serovars Enteritidis and Typhimurium determined by lipopolysaccharide enzyme-linked immunosorbent assay. Clin. Vaccine Immunol. 14, 741–747 (2007).

E. Vega et al., Novel surveillance network for norovirus gastroenteritis outbreaks, United States. Emerg. Infect. Dis. 17, 1389–1395 (2011).

X. Jiang, M. Wang, D. Y. Graham, M. K. Estes, Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein. J. Virol. 66, 6527–6532 (1992).

See Also

usa_enterics

ben-arnold/tmleAb documentation built on May 12, 2019, 10:55 a.m.