usa_enterics: dataset: United States enteric pathogen multiplex antibody...

In ben-arnold/tmleAb: Targeted maximum likelihood estimation for antibody measurements

Description

IgG antibody responses to protozoan, bacterial, and viral enteric pathogens measured with a multiplex bead assay in sample sets collected from 86 anonymous blood donors in the USA. There is one record per child. All antibody levels were measured on the Luminex platform and are in units of median flourescence intensity minus background (MFI-bg). A comparable dataset (and run with the same bead set) for children in Haiti is also included in the package: haiti_enterics.

Usage

data(usa_enterics)

Format

A data frame with 86 observations and 10 variables.

id

individual ID

age

age in years. Note that age records years completed, except for children <1 year old.

cp17

response (MFI-bg) to Cryptosporidium parvum recombinant 17-kDa antigen

cp23

response (MFI-bg) to Cryptosporidium parvum recombinant 27-kDa antigen

vsp5

response (MFI-bg) to the VSP-5 fragment of Giardia intestinalis variant-specific surface protein 42e

leca

response (MFI-bg) to Entamoeba histolytica lectin adhesion molecule (LecA)

etec

response (MFI-bg) to Enterotoxigenic Escherichia coli (ETEC) heat labile toxin β subunit

salb

response (MFI-bg) to lipopolysaccharide (LPS) from Salmonella enterica serotype Typhimurium (Group B)

norogii

response (MFI-bg) to purified recombinant norovirus GII.4 New Orleans virus-like particles from a baculovirus expression system

norogi

response (MFI-bg) to purified recombinant norovirus GI.4 virus-like particles from a baculovirus expression system

References

A. C. McDonald et al., Cryptosporidium parvum-specific antibody responses among children residing in Milwaukee during the 1993 waterborne outbreak. J. Infect. Dis. 183, 1373–1379 (2001).

D. M. Moss et al., Longitudinal Evaluation of Enteric Protozoa in Haitian Children by Stool Exam and Multiplex Serologic Assay. The American Journal of Tropical Medicine and Hygiene 90 (4): 653–60 (2014).

D. M. Moss, J. M. Montgomery, S. V. Newland, J. W. Priest, P. J. Lammie, Detection of cryptosporidium antibodies in sera and oral fluids using multiplex bead assay. J. Parasitol. 90, 397–404 (2004).

J. W. Priest et al., Multiplex assay detection of immunoglobulin G antibodies that recognize Giardia intestinalis and Cryptosporidium parvum antigens. Clin. Vaccine Immunol. 17, 1695–1707 (2010).

E. Houpt et al., Prevention of intestinal amebiasis by vaccination with the Entamoeba histolytica Gal/GalNac lectin. Vaccine. 22, 611–617 (2004).

J. Flores et al., Enterotoxigenic Escherichia coli Heat-Labile Toxin Seroconversion in US Travelers to Mexico. J. Travel Med. 15, 156–161 (2008).

M. A. Strid, T. Dalby, K. Mølbak, K. A. Krogfelt, Kinetics of the human antibody response against Salmonella enterica Serovars Enteritidis and Typhimurium determined by lipopolysaccharide enzyme-linked immunosorbent assay. Clin. Vaccine Immunol. 14, 741–747 (2007).

E. Vega et al., Novel surveillance network for norovirus gastroenteritis outbreaks, United States. Emerg. Infect. Dis. 17, 1389–1395 (2011).

X. Jiang, M. Wang, D. Y. Graham, M. K. Estes, Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein. J. Virol. 66, 6527–6532 (1992).

See Also

haiti_enterics

ben-arnold/tmleAb documentation built on May 12, 2019, 10:55 a.m.