scoring.boot: Calculating differential score

Description Usage Arguments Value Author(s)

Description

This function calculates standard errors for edge-wise partial correlation differences obtained from DIGNO model.

Usage

1
scoring.boot(stddat,z,Omega,A,B,boot.B=100,verbose=T) 

Arguments

stddat

standardized nxp data with colnames as genename

z

a length n vector representing a binary covariate

Omega

a p x p precision matrix for std dat which implies the global network

A

p x p matrix of the MLE for the baseline covariance matrix which is obtained from A value of the Greg.em function.

B

p x 2 matrix of the MLE for the regression coefficient which is obtained from B value of the Greg.em function

boot.B

a scalar indicating the number of bootstraps

verbose

if TRUE, lists the bootstrap replications

Value

genepair

a p(p-1)/2 x 2 matrix indicating all pairs of genes

levels.z

a length 2 vector indicating levels of the binary covariate z, the first element is for group 1 and the second element is for group 2

R1

a length p(p-1)/2 vector indicating partial correlations for group 1 and the order is corresponding to the order of genepair

R2

a length p(p-1)/2 vector indicating partial correlations for group 2 and the order is corresponding to the order of genepair

boot.diff

a p(p-1)/2 x boot.B matrix indicating bootstrapped difference, Fisher's Z transformed R1 - R2. The rows are corresponding to the order of gene pair and the columns are corresponding to the bootstrap samples

diff.score

a p(p-1)/2 vector of differential score corresponding to genepair

Author(s)

Min Jin HA mjha@mdanderson.org


berryni/mDINGO documentation built on May 24, 2019, 3:04 a.m.