SetBiologicalZeros: Set biological zeros
In beyergroup/ADImpute: Adaptive Dropout Imputer (ADImpute)

Description Usage Arguments Details Value

SetBiologicalZeros sets some of the entries back to zero after dropout imputation, as they likely correspond to true biological zeros (genes not expressed in given cell)

1	SetBiologicalZeros(imputation, drop_probs, thre = .2, was_zero)

`imputation`	matrix; imputed values
`drop_probs`	matrix; dropout probabilities for each entry in `imputation`. 0 means certain biological zero, while 1 means certain dropout to be imputed
`thre`	numeric; probability threshold to classify entries as biological zeros
`was_zero`	matrix; logical matrix: was the corresponding entry of `imputation` originally a zero?

Entries which were originally zero and have dropout probability below thre are considered biological zeros and, if they were imputed, are set back to 0.

matrix containing likely biological zeros set back to 0.

beyergroup/ADImpute documentation built on Dec. 19, 2021, 8:48 a.m.