bhklab/wCI: Modified Concordance Index

The concordance index (CI) is a widely used to assess the predictive value of biomedical assays. CI has previously been used in cell line-based drug screening to estimate the probability that two randomly-chosen cell lines are ranked identically across biological replicates or independent studies based on their drug response. However, the conventional formulation of CI does not account for the high level noise in drug response measurements. Here we introduce the wCI package implementing a modification of the concordance index (CI), called the robust concordance index (rCI) to explicitly accounts for the intrinsic variability of the pharmacological assays. For more details please see the included documentation.

install.packages("remotes")
remotes::install_github("bhklab/wCI")