mDrugEnrich: The drugs activity on 1001 genes

In bigomics/SPACEconnect: Stratified Perturbation Analysis by Correlation Enrichment of connectivity

The drugs activity on 1001 genes

Description

a large matrix represents the gene expression fold change of 1001 genes in the presence of 20220 different drugs concentrations and working time.

Usage

data("mDrugEnrich")

Format

The format is: num [1:1001, 1:20220] -12.7 0.82 -1.48 -1.89 4.02 ... - attr(*, "dimnames")=List of 2 ..$ : chr [1:1001] "PSME1" "CISD1" "SPDEF" "ATF1" ... ..$ : chr [1:20220] "crizotinib_HEPG2_10um_24h" "avicin-d_JURKAT_10um_24h" "BRD-K35716340_WSUDLCL2_10um_6h" "trequinsin_HCC515_0.4um_24h" ...

Details

The LINCS L1000 project has collected gene expression profiles for thousands of perturbagens at a variety of time points, doses, and cell lines. A full list of the chemical and genetic perturbations used can be found on the CLUE website along with their descriptions.

Source

https://lincsproject.org/LINCS/tools/workflows/find-the-best-place-to-obtain-the-lincs-l1000-data

References

Duan Q et al. LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures. Nucleic Acids Res. 2014 Jul;42 (Web Server issue):W449-60.

Examples

data(mDrugEnrich)
## maybe str(mDrugEnrich) ; plot(mDrugEnrich) ...

bigomics/SPACEconnect documentation built on March 19, 2022, 3:39 a.m.