mFC: Fold change matrix of differential gene expresion from RNAseq...

In bigomics/SPACEconnect: Stratified Perturbation Analysis by Correlation Enrichment of connectivity

Fold change matrix of differential gene expresion from RNAseq data of Multiple myeloma

Description

There are 6 contrasts : 1- glucocorticoid sensitive vs glucocorticoid resistant ("Resistant.vs.Sensitive").2- Treated with Withaferin-A vs untreated ("WithaferinA.vs.Untreated"). 3- untreated glucocorticoid resistant cells vs untreated glucocorticoid sensitive cells ("UTR.vs.UTS"). 4- Treated with Withaferin-A glucocorticoid resistant cells vs Treated with Withaferin-A glucocorticoid sensitive cells ("WAR.vs.WAS"). 5- Treated Resistant vs Untreated Resistant ("WAR.vs.UTR"). 6- Treated sensitive vs Untreated sensitive ("WAS.vs.UTS")

Usage

data("mFC")

Format

A data frame with 5332 observations on the following 6 variables.

Resistant.vs.Sensitive

a numeric vector

WithaferinA.vs.Untreated

a numeric vector

UTR.vs.UTS

a numeric vector

WAR.vs.WAS

a numeric vector

WAR.vs.UTR

a numeric vector

WAS.vs.UTS

a numeric vector

Details

The RNAseq data from (Logie et al 2021) study. They compared the therapeutic efficacy of the phytochemical kinase inhibitor withaferin A with the clinically approved BTK inhibitor ibrutinib to target hyperactivated tyrosine kinase signaling in glucocorticoid-resistant multiple myeloma cells. The results demonstrate that withaferin-A induced cell death of glucocorticoid-resistant MM1R cells involves covalent cysteine targeting of multiple Hinge-6 domain type tyrosine kinases of the kinase cysteinome classification, including BTK.

Source

GEO accession number GSE162475

References

Logie E, Chirumamilla CS, Perez-Novo C, Shaw P et al. Covalent Cysteine Targeting of Bruton's Tyrosine Kinase (BTK) Family by Withaferin-A Reduces Survival of Glucocorticoid-Resistant Multiple Myeloma MM1 Cell. Cancers (Basel) 2021 Mar 31;13(7). PMID: 33807411

Examples

data(mFC)
## maybe str(mFC) ; plot(mFC) ...

bigomics/SPACEconnect documentation built on March 19, 2022, 3:39 a.m.